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Published on: March 10, 2020
[Esophageal atresia and chromosomal abnormalities in a Mexican children population: descriptive analysis]
J F González-Zamora1, F Villegas-Alvarez
1Laboratorio de Cirugía Experimental, Instituto Nacional de Pediatría, México.
Introduction:
Chromosome alterations are associated with esophageal atresia (EA) in up to 11% of the cases. The morbidity and mortality index of this population is different from other EA patients. The present study was aimed to determine the characteristics of this association in a Mexican infant patient population.
Material And Methods:
Observational, descriptive, retrospective, transversal assay including patients with AE and chromosome alterations over a 31-year period. Gestational age, admittance age, sex, type of atresia, chromosome alteration, additional malformations, treatment, evolution and death cause, were registered.
Results:
Seventeen patients (4.61%) out of 368 with EA were included. Chromosome 21 trisomy was detected in 12 children and 5 with 18 trisomy. One to 3 additional malformations were found in 16 patients. Fifteen children were subjected to surgical procedures for EA, and 6 for associated malformations. Fourteen children died in a 140-day follow-up period.
Conclusions:
Coexistence between AE, trisomys and major malformations was characterized by multifactorial complications which determined adverse evolution in the short term.
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