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[Study on the relationship between polymorphism of ApoE gene and TCM syndrome type of primary hyperlipemia]
Wei-Min Jiang1, Shu-Hua Tang, Ren-Sheng Lai
1Department of Cardiovascular Diseases, The First Affiliated Hospital of Nanjing University of Traditional Chinese Medicine, Nanjing. jiangweimin0410@yahoo.com.cn
Objective:
To study the relationship between the polymorphism of ApoE gene and TCM syndrome type of primary hyperlipemia.
Methods:
ApoE genotype of 102 patients with hyperlipemia was detected by gene PCR sequencing.
Results:
A total of five genotypes were detectable, they were E2/2, E3/3, E4/4, E2/3 and E3/4. The frequency of E3/4 + E4/4 and epsilon4 allelotype detected in the patients of Gan-Shen Yin deficiency syndrome type were significantly higher than those in patients of Pi-Shen Yang-deficiency type or of phlegm stagnation type (P < 0.05, P < 0.01), and which in patients of Qi-stagnation caused blood stasis type were significantly higher than those in patients of phlegm stagnation type ( P < 0.05).
Conclusion:
Polymorphism of ApoE gene is related in a certain degree to TCM syndrome type of primary hyperlipemia.
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