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Related Experiment Videos

Chronic progressive autonomic dysfunction in a dog.

K K Adamama-Moraitou1, G D Brellou, T S Rallis

  • 1Companion Animal Clinic (Medicine), Faculty of Veterinary Medicine, Aristotle University of Thessaloniki, 11 St. Voutyra str., GR-54 627, Thessaloniki, Greece. kadamama@vet.auth.gr

Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine
|February 10, 2006
PubMed
Summary

A dog diagnosed with autonomic dysfunction showed progressive symptoms including urinary incontinence, constipation, and regurgitation. Histopathology revealed inflammatory degenerative neuropathy of autonomic ganglia, similar to human autonomic failure.

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Area of Science:

  • Veterinary Neurology
  • Autonomic Nervous System Disorders
  • Comparative Pathology

Background:

  • Autonomic dysfunction can manifest with a range of clinical signs in animals.
  • Early diagnosis and understanding of underlying neuropathology are crucial for managing complex cases.

Observation:

  • A 3.5-year-old male American Pit Bull presented with urinary incontinence and dysuria.
  • Over four years, the dog developed progressive signs including constipation, diarrhea, ocular disturbances, and regurgitation.
  • Clinical signs and diagnostic tests (pilocarpine, Schirmer tear test) indicated autonomic dysfunction.

Findings:

  • Histopathological and immunohistochemical examination revealed lesions consistent with inflammatory degenerative neuropathy affecting autonomic ganglia.

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  • The observed neuropathy mirrors types of autonomic failure seen in human medicine.

    • Implications:

    • This case highlights inflammatory degenerative neuropathy as a cause of autonomic failure in canines.
    • Findings contribute to understanding comparative autonomic neuropathology between species.
    • Suggests potential for similar diagnostic and therapeutic approaches in veterinary and human medicine.