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Response to immunization against polio after allogeneic marrow transplantation
P Ljungman1, V Duraj, L Magnius
1Department of Medicine, Karolinska Institute, Huddinge, Sweden.
Bone Marrow Transplantation
|February 1, 1991
Summary
Long-term immunity to poliovirus wanes after allogeneic bone marrow transplantation (BMT). Reimmunization with inactivated poliovirus vaccine (IPV) is crucial, with a three-dose schedule recommended for adequate antibody responses in BMT recipients.
Area of Science:
- Immunology
- Virology
- Hematology
Background:
- Allogeneic bone marrow transplantation (BMT) can impact long-term immunity.
- Poliovirus immunity and vaccine response in BMT patients require further investigation.
Purpose of the Study:
- To assess poliovirus immunity and inactivated poliovirus vaccine (IPV) response in patients post-BMT.
- To determine the efficacy of different IPV immunization schedules in BMT recipients.
Main Methods:
- Studied 55 patients before and after BMT, and after IPV immunization.
- Antibody levels were measured using neutralization assays.
- Assessed response to one-dose and three-dose IPV schedules.
Main Results:
- A significant decrease in poliovirus antibody levels was observed 12 months post-BMT.
- Response rates to a single IPV dose were suboptimal for all poliovirus types.
- A three-dose IPV schedule yielded higher response rates (52% for type 1, 48% for types 2 and 3).
Conclusions:
- Allogeneic BMT recipients require reimmunization against poliovirus.
- A three-dose inactivated poliovirus vaccine schedule is necessary for adequate immunization response.
- Immunization response was not significantly affected by chronic GVHD.