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Published on: July 16, 2018
The complex between activated protein C and protein C inhibitor: A clinically useful indicator of aortic aneurysms?
J Stenflo1, M Kjellberg, K Strandberg
1Department of Clinical Chemistry, Lund University, University Hospital, Malmö, S205 02 Malmö, Sweden. Johan.Stenflo@klkemi.mas.lu.se
Abstract:
The concentration of the complex between activated protein C and the protein C inhibitor reflects the degree of activation of blood coagulation. A sandwich method has been devised that measures the complex concentration in blood plasma. A key feature of the method is that the catching monoclonal antibody recognizes a complex-dependent neoepitope in PCI, which is a prerequisite, since the concentration of uncomplexed PCI is approximately 10(4)-fold higher than that of the complex. In patients with atherosclerotic disease, those with aortic aneurysms exhibit a three-fold increase in complex concentration compared to that of normal subjects.
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