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Related Experiment Videos

Deep-breath frequency in bronchoconstricted monkeys (Macaca fascicularis).

Joseph M Dybas1, Catharine J Andresen, Edward S Schelegle

  • 1Biomedical Engineering Dept., Boston Univ., 44 Cummington St., Boston, MA 02215, USA.

Journal of Applied Physiology (Bethesda, Md. : 1985)
|February 10, 2006
PubMed
Summary

Deep-breath frequency increases with certain bronchoconstriction methods, particularly those involving Ascaris suum and histamine. This suggests vascular permeability influences rapidly adapting receptor activity in asthma.

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Area of Science:

  • Respiratory Physiology
  • Pulmonary Medicine

Background:

  • Deep-breath frequency increases in asthmatic subjects with spontaneous airway obstruction.
  • Lung rapidly adapting receptors regulate deep breaths, but their stimulation mechanism is unclear.

Purpose of the Study:

  • To test if deep-breath frequency increases during experimentally induced bronchoconstriction.
  • To determine if the magnitude of increased deep-breath frequency depends on the method of bronchoconstriction.

Main Methods:

  • Nine cynomolgus monkeys were challenged with methacholine, Ascaris suum, histamine, or external mechanical resistance.
  • Deep-breath frequency, airway resistance (Raw), tissue compliance (Cti), and ventilatory parameters were measured.
  • Transfer impedance and airway flow measurements were used to analyze respiratory and ventilatory parameters.

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Main Results:

  • Deep-breath frequency significantly increased with Ascaris suum and histamine challenges compared to baseline.
  • Methacholine and external resistance challenges did not significantly alter deep-breath frequency.
  • All challenges caused similar bronchoconstriction, but Ascaris suum and histamine decreased non-deep-breath tidal volume.

Conclusions:

  • Increased deep-breath frequency during Ascaris suum and histamine challenge may result from increased vascular permeability.
  • This vascular permeability likely enhances rapidly adapting receptor activity, influencing breathing patterns in bronchoconstriction.