Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Morphine-ethanol interaction on body temperature.

A Orts1, C Alcaraz, L Goldfrank

  • 1Department of Anesthesiology, New York University Medical Center, NY 10016.

General Pharmacology
|January 1, 1991
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Agricultural policies against invasive species generate contrasting outcomes for climate change mitigation and biodiversity conservation.

Proceedings. Biological sciences·2022
Same author

Rapid detection of ciguatoxins in Gambierdiscus and Fukuyoa with immunosensing tools.

Ecotoxicology and environmental safety·2020
Same author

Photoelectron spectroscopy of boron-containing reactive intermediates using synchrotron radiation: BH<sub>2</sub>, BH, and BF.

Physical chemistry chemical physics : PCCP·2019
Same author

Experimental and theoretical threshold photoelectron spectra of methylene.

The Journal of chemical physics·2018
Same author

Communication: On the first ionization threshold of the C<sub>2</sub>H radical.

The Journal of chemical physics·2017
Same author

Characterization of stress coping style in Senegalese sole (<i>Solea senegalensis</i>) juveniles and breeders for aquaculture.

Royal Society open science·2016
Same journal

Endothelium-dependent vasorelaxant and antiproliferative effects of apigenin.

General pharmacology·2002
Same journal

Reversal of hypercapnia induces endothelin-dependent constriction of basilar artery in rabbits with acute metabolic alkalosis.

General pharmacology·2002
Same journal

Reversal of hypercapnia induces KATP channel and NO-independent constriction of basilar artery in rabbits with acute metabolic alkalosis.

General pharmacology·2002
Same journal

Contractile responses in spontaneously diabetic mice. II. Effect of cholestyramine on enhanced contractile response of aorta to norepinephrine in C57BL/KsJ (db/db) mice.

General pharmacology·2002
Same journal

Contractile responses in spontaneously diabetic mice. I. Involvement of superoxide anion in enhanced contractile response of aorta to norepinephrine in C57BL/KsJ(db/db) mice.

General pharmacology·2002
Same journal

Investigation of basal endothelial function in the obese Zucker rat in vitro.

General pharmacology·2002
See all related articles

Ethanol and morphine both lower mouse body temperature. Their combined effect is less than additive, and not due to changes in drug levels or receptor binding.

Area of Science:

  • Pharmacology
  • Neuroscience

Background:

  • Ethanol and morphine are commonly used substances with known physiological effects.
  • Understanding their interaction is crucial for predicting combined effects and potential risks.

Purpose of the Study:

  • To investigate the interaction between ethanol and morphine on core body temperature in mice.
  • To determine if the hypothermic effects are additive and the role of opioid receptors in this interaction.

Main Methods:

  • Swiss Webster mice were administered varying doses of morphine and ethanol, individually and concurrently.
  • Core body temperature was monitored, and naloxone was used to assess opioid receptor involvement.
  • Plasma drug levels and naloxone binding to opiate receptors were measured.

Related Experiment Videos

Main Results:

  • Both morphine and ethanol produced dose-dependent hypothermia when administered alone.
  • The combined administration of morphine and ethanol resulted in a hypothermic effect that was less than additive.
  • High doses of naloxone were required to reverse the hypothermic effects of ethanol and the combination.
  • Ethanol did not significantly alter morphine or ethanol plasma levels, nor did it affect naloxone binding to opiate receptors.

Conclusions:

  • The interaction between morphine and ethanol on core body temperature is less than additive.
  • This interaction is not mediated by pharmacokinetic changes in either drug or by alterations in opiate receptor binding.
  • The findings suggest a complex interplay between ethanol and morphine beyond simple additive effects at the opioid receptor level.