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Intravitreal toxicity of moxifloxacin

Erdinc Aydin1, Abdul Ahad Kazi, Gholam A Peyman

  • 1Department of Ophthalmology, Tulane University Health Sciences Center, 1430 Tulane Avenue SL-69, New Orleans, LA 70112-2699, USA.

Retina (Philadelphia, Pa.)
|February 10, 2006
PubMed
Abstract

Insights

Intravitreal moxifloxacin at concentrations up to 160 microg/0.1 mL showed no retinal toxicity in rabbit eyes. Higher concentrations (320 microg/0.1 mL) caused significant electroretinography changes, indicating potential toxicity.

Area of Science:

  • Ophthalmology
  • Toxicology
  • Pharmacology

Background:

  • Fluoroquinolones are widely used antibiotics.
  • Intravitreal injections are common for treating eye conditions.
  • Assessing the safety of intravitreal antibiotics is crucial.

Purpose of the Study:

  • To evaluate the retinal toxicity of varying concentrations of intravitreally administered moxifloxacin.
  • To determine the safety threshold for moxifloxacin in ocular tissues.

Main Methods:

  • Moxifloxacin was administered intravitreally to New Zealand albino rabbits at concentrations of 50, 100, 160, and 320 microg/0.1 mL.
  • Control groups received 5% dextrose solution.
  • Ocular examinations included indirect ophthalmoscopy, slit-lamp biomicroscopy, electroretinography (ERG), and light microscopy.

Main Results:

  • Significant decreases in ERG findings were observed at 320 microg/0.1 mL moxifloxacin.
  • No meaningful ERG changes or signs of retinal toxicity were noted at concentrations <= 160 microg/0.1 mL.
  • Histopathological examination and clinical assessments confirmed safety at lower concentrations.

Conclusions:

  • Intravitreal moxifloxacin at concentrations up to 160 microg/0.1 mL is considered safe for the rabbit retina.
  • Higher concentrations (320 microg/0.1 mL) may pose a risk of retinal toxicity.

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