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Bullous reaction to topical methchlorethamine in mycosis fungoides
Jeff Freed1, Michael Wells, Cloyce Stetson
1Department of Dematology, Texas Tech University Health Science Center, Lubbock, TX 79430, USA. mjwells@pol.net
Abstract:
We describe a patient with mycosis fungoides who developed a bulla shortly after the start of topical methchlorethamine. Dermal-epidermal separation has been reported to occur with topical methchlorethamine on histological examination. It is plausible that the compromised dermal-epidermal junction may manifest as a clinical bulla after a secondary insult. To our knowledge, clinical bulla formation due to topical methchlorethamine has not been reported.
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