Related Experiment Video
Updated: Aug 11, 2026
A Rat Model of Middle Cerebral Artery Occlusion/Reperfusion Without Damaging the Anatomical Structure of Cerebral Vessels
Published on: May 17, 2024
[Expression of Cyt C in brain of rats poisoned by tetramine]
Bin Li1, Wei-jia Chen, Hong-tao Yan
1Department of Forensic Pathology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu 610041, China.
Objective:
To investigate the evidence for the judgement on legal cases of intoxication by tetramine.
Methods:
Fifty rats given tetramine by lavage were sacrificed at different time after intoxication. The expression of Cyt C was detected by immunohistochemistry, and the reasults were assessed by an image analysis system.
Results:
There was a slight expression of Cyt C in control group. In intoxication group the expression of Cyt C increased after the rats were given tetramine for 30 minutes; it reached the peak at 24 hours after intoxication and kept up the level for 3 days, then it began to decrease and returned to the control level in 10 days.
Conclusion:
The regular change of Cyt C expression might be a useful sign for assessment in legal cases of intoxication by tetramine.
