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Updated: Jul 25, 2026
Formulation of Diblock Polymeric Nanoparticles through Nanoprecipitation Technique
Published on: September 20, 2011
[The pharmacokinetic study on cytarabine nanoparticle lyophilization injection in rabbits]
Jing Zhou1, Xue-hua Jiang, Lin He
1Department of Clinical Pharmacy, West China School of Pharmacy, Sichuan University, Chengdu 610041, China.
Objective:
The pharmacokinetics of Cytarabine Polybutylcyanoacrylate Nanoparticles (Ara-C-PBCA-NP) lyophilization injection in rabbits was studied.
Methods:
Ara-C water solution was taken as reference, the concentration of Ara-C was determined by HPLC, and the pharmacokinetic parameters were calculated.
Results:
Pharmacokinetic properties of Ara-C water solution and Ara-C-PBCA-NP lyophilization injection complied with two-department model. The parameters t1/2 beta and MRT of Ara-C-PBCA-NP lyophilization injection were prolonged, and CL was reduced dramatically (P < 0.05).
Conclusion:
Ara-C-PBCA-NP lyophilization injection possesses prolonged retention time in vivo and significant sustained releasing character.
