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Updated: Aug 1, 2026
Murine Renal Transplantation Procedure
Published on: July 10, 2009
Successful renal transplantation in patients with chronic granulomatous disease
A Bolanowski1, R B Mannon, S M Holland
1Department of Surgery, National Naval Medical Center, Bethesda, Maryland, USA.
Insights
This study shows successful kidney transplantation outcomes in patients with Chronic Granulomatous Disease (CGD), even with immunosuppression. Multidisciplinary care is crucial for managing CGD patients undergoing transplantation.
Area of Science:
- Immunology
- Genetics
- Nephrology
Background:
- Chronic Granulomatous Disease (CGD) is a severe genetic immunodeficiency caused by NADPH oxidase mutations.
- End-stage renal disease (ESRD) is common in CGD patients, often linked to nephrotoxic medications.
Observation:
- This report details three CGD patients undergoing kidney transplantation across two centers.
- Transplant approaches included simultaneous CGD and kidney transplant, sequential bone marrow and kidney transplant, and kidney transplant followed by stem cell transplant for CGD cure.
Findings:
- All three patients achieved excellent outcomes post-transplantation.
- Immunosuppressive therapy appeared to have benign effects in these CGD patients.
- A multidisciplinary and meticulous approach is essential for successful transplantation in CGD.
Implications:
- Kidney transplantation is a viable option for CGD patients with ESRD.
- Further research into immunosuppression in CGD transplant recipients is warranted.
- Optimized, multidisciplinary care pathways can improve outcomes for CGD patients requiring transplantation.
Abstract:
Chronic granulomatous disease (CGD) is a genetic disease caused by structural mutations in the enzyme NADPH oxidase that results in severe immunodeficiency. End-stage renal disease occurs in this patient population, and is often attributed to the necessary use of nephrotoxic anti-infectives. In this report, we present the experiences of two centers in transplantation of three patients with CGD: one transplanted with CGD, one cured of his CGD with bone marrow transplantation who subsequently underwent kidney transplantation and one that received a kidney transplant prior to being cured of CGD via a sequential peripheral blood stem cell transplant (SCT). All three recipients have enjoyed excellent outcomes. Their courses demonstrate the absolute requirements for a multidisciplinary and compulsive approach before, during and after transplantation. These case reports also highlight the unexpectedly benign effects of immunosuppressive therapy in this patient population.
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