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Updated: Aug 11, 2026

Fetal Echocardiography and Pulsed-wave Doppler Ultrasound in a Rabbit Model of Intrauterine Growth Restriction
Published on: June 29, 2013
Intrauterine growth restriction
K Haram1, E Søfteland, R Bukowski
1Department of Obstetrics and Gynecology, Haukeland University Hospital, Bergen, Norway. kjell.haram@broadpark.no
Insights
This review covers screening, diagnosis, and treatment for intrauterine growth restriction (IUGR). Early detection and specific interventions like aspirin can improve outcomes for high-risk pregnancies.
Area of Science:
- Obstetrics and Gynecology
- Fetal Medicine
Background:
- Intrauterine growth restriction (IUGR) is a significant concern in perinatal medicine.
- Accurate screening and diagnosis are crucial for effective management.
Purpose of the Study:
- To review current evidence on the screening, diagnosis, prophylaxis, and treatment of IUGR.
- To identify best practices for managing fetal growth restriction.
Main Methods:
- Literature search of PubMed and Cochrane databases.
- Systematic review of studies on IUGR screening, diagnosis, and management.
Main Results:
- Screening relies on risk factors and symphysis-fundus height; diagnosis is confirmed by ultrasonography.
- Improved diagnostic accuracy may be achieved with customized growth curves, charts, and advanced Doppler ultrasonography.
- Prophylaxis with acetylsalicylic acid or heparin, and targeted treatment of infections or asthma, may reduce IUGR incidence.
- Antenatal corticosteroids reduce perinatal morbidity and mortality; bed rest is ineffective.
Conclusions:
- Current screening and diagnostic methods for IUGR are established but can be enhanced.
- Specific prophylactic and therapeutic strategies show promise in reducing IUGR incidence and improving perinatal outcomes.
Abstract:
This study reviewed the screening, diagnosis, prophylaxis, and treatment of intrauterine growth restriction using the PubMed database for key words and the Cochrane database for systematic reviews. Identification of risk factors and measurement of symphysis-fundus height are currently the screening standards. Diagnosis is verified by ultrasonography. Accuracy of diagnosis may be improved by using customized fetal growth curves, symphysis-fundus height charts, and 3-dimensional ultrasonographic evaluation and measuring umbilical artery Doppler dimensional ultrasonographic evaluation measuring umbilical artery Doppler impedance. Prophylaxis with acetylsalicylic acid, started in the first or second trimester or combined with heparin before conception, may reduce the incidence of growth restriction in specific groups at high risk. Active management may reduce incidence in patients with mild to moderate asthma, and targeted treatment of infections may also be beneficial. Antenatal corticosteroid treatment also reduces the perinatal morbidity and mortality associated with IUGR. Bed rest has no demonstrated beneficial effects.
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