Related Experiment Video

Updated: Aug 11, 2026

Computed Tomography (CT) Guided Implantation of a Totally Implantable Venous Access Port (TIVAP) through Subclavian Vein
05:51

Computed Tomography (CT) Guided Implantation of a Totally Implantable Venous Access Port (TIVAP) through Subclavian Vein

Published on: January 13, 2026

[Central venous totally implantable access for high dose chemotherapy in children]

C Conter1, L Carausu, E Martin

  • 1Centre Léon-Bérard, 28, rue Laennec, 69008 Lyon, France. conter@lyon.fnclcc.fr

Archives De Pediatrie : Organe Officiel De La Societe Francaise De Pediatrie
|February 14, 2006
PubMed

Insights

Totally implantable access ports (TIAP) are a safe option for high-dose chemotherapy (HDC) in children undergoing stem cell transplantation. TIAP showed fewer infectious complications but more mechanical issues compared to external catheters (EC).

Area of Science:

  • Pediatric Oncology
  • Vascular Access Devices
  • Hematopoietic Stem Cell Transplantation

Background:

  • Central venous totally implantable access ports (TIAP) are underutilized for high-dose chemotherapy (HDC) with autologous stem cell transplantation.
  • Previous studies on TIAP feasibility and complication rates in this pediatric setting are limited.

Purpose of the Study:

  • To investigate and compare the infectious and mechanical complication rates of TIAP versus external catheters (EC).
  • To evaluate the safety and efficacy of TIAP in pediatric patients undergoing HDC and autologous stem cell transplantation.

Main Methods:

  • Retrospective study of 64 pediatric patients receiving HDC and autologous stem cell transplantation.
  • Analysis of infectious and mechanical complications in 45 TIAP and 19 EC devices.
  • Data collected between January 1999 and December 2003.

Main Results:

  • TIAP had a lower rate of catheter-related bloodstream infections (8.9%) compared to EC (15.8%).
  • Mechanical complications, including reversible obstruction, were more frequent with TIAP (6/7 cases).
  • No deep vein thrombosis was observed; TIAP also served for progenitor cell collection in some cases.

Conclusions:

  • Totally implantable access ports (TIAP) are a safe and effective alternative for HDC in pediatric patients.
  • TIAP demonstrate a favorable infectious complication profile but require careful monitoring for mechanical issues.
  • Prospective validation in a larger cohort is recommended to confirm these findings.
Abstract

More Related Videos

Intracranial Cannula Implantation for Serial Locoregional Chimeric Antigen Receptor (CAR) T Cell Infusions in Mice05:22

Intracranial Cannula Implantation for Serial Locoregional Chimeric Antigen Receptor (CAR) T Cell Infusions in Mice

Published on: February 24, 2023

Related Concept Videos

Parenteral Drug Delivery Systems: Injectables, Implants, and Infusion Devices01:28

Parenteral Drug Delivery Systems: Injectables, Implants, and Infusion Devices

Parenteral drug delivery systems play a crucial role in modern therapeutics by enabling the direct administration of drugs into the systemic circulation, bypassing the gastrointestinal tract. These systems are particularly valuable for poorly absorbed oral medications that are unstable in the digestive environment or require rapid onset or sustained therapeutic levels. Delivery is achieved through intravenous, intramuscular, or subcutaneous routes, each selected based on the drug's properties...
Parentral Nutrition: Centeral and Peripheral Parental Nutrition01:27

Parentral Nutrition: Centeral and Peripheral Parental Nutrition

Parenteral Nutrition (PN) delivers essential nutrients directly into the bloodstream, bypassing the digestive system. It is commonly used for individuals with severe digestive disorders or conditions that prevent normal nutrient absorption.
PN can be administered through two primary routes:
1. Central Parenteral Nutrition (CPN):
CPN involves delivering a high concentration of nutrients through a large vein. This is typically achieved using a Peripherally Inserted Central Catheter (PICC) or,...
Extracorporeal Removal of Drugs: Continuous Renal Replacement Therapy01:26

Extracorporeal Removal of Drugs: Continuous Renal Replacement Therapy

Continuous Renal Replacement Therapy (CRRT) is an essential intervention for patients experiencing severe kidney dysfunction. This therapy offers a continuous mechanism for removing fluids and toxins from the bloodstream, leveraging the patient’s blood pressure to facilitate filtration through a specialized filter. This method contrasts with intermittent dialysis, providing a gentler and more consistent removal of waste products and excess fluid, which is particularly beneficial in critically...
Drug Dosing: Infants and Children01:29

Drug Dosing: Infants and Children

Pediatric patient dosages diverge from adults due to disparities in body surface area, total body water, and extracellular fluid per kilogram of body weight. The dosing regimen considers the variations in pharmacokinetics and pharmacology across distinct age groups, encompassing preterm newborns, infants, young children, older children, and adolescents. Calculation of pediatric patient doses is predicated on determining body surface area, which exhibits a superior correlation with the child's...
Continuous Renal Replacement Therapy01:30

Continuous Renal Replacement Therapy

Continuous Renal Replacement Therapy, also known as CRRT, is a procedural treatment for acute kidney injury (AKI) that gradually removes uremic toxins and fluids while maintaining acid-base balance and stabilizing electrolytes. It is particularly useful for hemodynamically unstable patients. Unlike intermittent hemodialysis, which is faster, CRRT provides a gentler approach over 24 hours, closely mimicking the function of natural kidneys. However, CRRT is not ideal for patients with...
Endocarditis IV: Nursing Management01:29

Endocarditis IV: Nursing Management

Infective endocarditis (IE) is a chronic infection of the heart's endocardium, primarily affecting the heart valves. A detailed nursing assessment for a patient with IE involves collecting subjective and objective data to ensure an accurate diagnosis and timely intervention.Subjective DataThe nurse gathers information about the patient's symptoms and complaints during the subjective assessment. Patients with infective endocarditis often report non-specific symptoms that can mimic other...