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Updated: Aug 11, 2026

Multi-photon Intracellular Sodium Imaging Combined with UV-mediated Focal Uncaging of Glutamate in CA1 Pyramidal Neurons
Published on: October 8, 2014
Selective detection of ordered sodium signals via the central transition
Jennifer Choy1, Wen Ling, Alexej Jerschow
1Chemistry Department, New York University, New York, NY 10003, USA.
Abstract:
Given the correlation between the concentrations of ordered (23)Na and the onset of tissue disorders, the ability to select the signal from ordered (23)Na over that of free (23)Na is of particular importance and can greatly enhance the potential of (23)Na-MRI as a diagnostic tool. Here, we describe a simple method that selectively detects the central transition of ordered sodium while minimizing the signal from free sodium. Our method relies upon the influence of the quadrupolar interaction on nutation frequencies and may also benefit solid-state imaging experiments. Both a liquid crystalline environment and a cartilage sample are used to demonstrate a clean separation between anisotropic and isotropic regions in the experiments.

