Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Fructose 1,6-diphosphate administration attenuates post-ischemic ventricular dysfunction.

Jeffrey E Cohen1, Pavan Atluri, Matthew D Taylor

  • 1University of Pennsylvania, School of Medicine, Department of Surgery, Philadelphia, PA 19104, USA.

Heart, Lung & Circulation
|February 14, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Optimizing Lung Transplant Logistics Using Controlled Hypothermic Preservation to Extend Ischemic Time.

Transplantation direct·2026
Same author

Combination S100A1 and ARC gene therapy as a treatment for DMD cardiomyopathy.

JCI insight·2026
Same author

Direct Observation of Nanometer-Sized Steps of Single Myosin VI Molecules in Living Cells.

Nano letters·2026
Same author

Functional and structural pathologies in skeletal muscle of a rat model of Duchenne muscular dystrophy.

Skeletal muscle·2026
Same author

3'UTR Mapping Reveals Alternative Polyadenylation in Right Ventricular Failure.

Circulation research·2026
Same author

Altered cholesterol immunometabolism activates the macrophage NLRP3-inflammasome in lung fibrosis.

American journal of respiratory cell and molecular biology·2026

Fructose 1,6-diphosphate (FDP) administration improved heart function and energy levels during ischemia. This study shows FDP enhances myocardial bioenergetics and function following acute ischemia in rats.

Area of Science:

  • Cardiology
  • Biochemistry
  • Physiology

Background:

  • Cardiomyocyte energy production during ischemia relies on inefficient anaerobic glycolysis.
  • Fructose 1,6-diphosphate (FDP) offers an alternative metabolic pathway, bypassing key ATP-consuming steps to yield more energy.
  • This study investigates FDP's potential to improve cardiac function under ischemic conditions.

Purpose of the Study:

  • To evaluate the impact of FDP administration on myocardial function after acute ischemia.
  • To assess the effect of FDP on cardiac bioenergetics during ischemic events.

Main Methods:

  • Male Wistar rats underwent 30 minutes of left anterior descending coronary artery occlusion followed by 30 minutes of reperfusion.
  • Animals received intravenous FDP or saline control immediately before ischemia and reperfusion.

Related Experiment Videos

  • Myocardial function was assessed using a pressure/volume conductance microcatheter, and ATP levels were measured in ischemic myocardium.

    • Main Results:

    • FDP administration significantly improved maximal left ventricular pressure, dP/dt, ejection fraction, and preload-adjusted maximal power compared to controls.
    • ATP levels in ischemic myocardium were significantly higher in the FDP group than in the control group.
    • These findings demonstrate enhanced cardiac performance and bioenergetics with FDP treatment.

    Conclusions:

    • Intravenous administration of FDP, a glycolytic intermediate, significantly improves myocardial function post-ischemia.
    • FDP enhances cardiac bioenergetic efficiency during ischemic periods.
    • FDP represents a promising therapeutic strategy for managing myocardial ischemia.