Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

How the ER stays in shape.

Ruth N Collins1

  • 1Department of Molecular Medicine, College of Veterinary Medicine, Cornell University Ithaca, NY 14853, USA. rnc8@cornell.edu

Cell
|February 14, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Multi-platform omics analysis of Nipah virus infection reveals viral glycoprotein modulation of mitochondria.

Cell reports·2025
Same author

Cell cycle-dependent phosphorylation of Sec4p controls membrane deposition during cytokinesis.

The Journal of cell biology·2016
Same author

A lysine deacetylase Hos3 is targeted to the bud neck and involved in the spindle position checkpoint.

Molecular biology of the cell·2014
Same author

Phosphorylation provides a negative mode of regulation for the yeast Rab GTPase Sec4p.

PloS one·2011
Same author

Cell biology: A score for membrane fusion.

Nature·2009
Same author

Rab13 regulates membrane trafficking between TGN and recycling endosomes in polarized epithelial cells.

The Journal of cell biology·2008
Same journal

A viral ORFeome library for systems-level genetic dissection of host-pathogen interactions.

Cell·2026
Same journal

Co-option of lysosomal machinery shapes the evolution of the intracellular photosymbiosis supporting coral reefs.

Cell·2026
Same journal

LEF1 and niche factors determine T cell stemness across chronic diseases.

Cell·2026
Same journal

Recurrent patterns of TOP1-mediated neuronal genomic damage shared by major neurodegenerative disorders.

Cell·2026
Same journal

Four-dimensional molecular mapping from a spatial snapshot reveals the dynamics of hair follicle organogenesis.

Cell·2026
Same journal

Whole-cell particle-based digital twin simulations from 4D lattice light-sheet microscopy data.

Cell·2026
See all related articles

Two proteins, Reticulon 4a (Rtn4a/NogoA) and DP1/Yop1p, shape the endoplasmic reticulum (ER) into tubules. Their unique membrane structure is key to generating ER curvature and tubular morphology.

Area of Science:

  • Cell biology
  • Molecular mechanisms of organelle architecture

Background:

  • Organelle architecture is crucial for cellular function.
  • The endoplasmic reticulum (ER) exists in complex tubular and sheet-like structures.

Purpose of the Study:

  • To identify the molecular components responsible for the tubular morphology of the endoplasmic reticulum (ER).

Main Methods:

  • The study focused on identifying specific membrane proteins involved in ER structure.

Main Results:

  • Reticulon 4a (Rtn4a/NogoA) and DP1/Yop1p were identified as key proteins.
  • These proteins are responsible for generating the tubular morphology observed in the ER.
  • The unusual membrane topology of Rtn4a/NogoA and DP1/Yop1p likely contributes to ER curvature.

Related Experiment Videos

Conclusions:

  • Rtn4a/NogoA and DP1/Yop1p play a critical role in determining ER shape.
  • Understanding these proteins advances knowledge of organelle morphogenesis and membrane biophysics.