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Updated: Aug 11, 2026

Efficient Sampling of Genetically Encoded Biosensor Design Space Enabled with a Design of Experiments and Automation Workflow
Published on: October 17, 2025
[Rational evolutionary design and modification of gene: a short-path of direct evolution]
Ai-Sheng Xiong1, Quan-Hong Yao, Zhen Zhang
1College of Horticulture, Nanjing Agricultural University, Nanjing 210095, China. aishengxiong@yahoo.com
Abstract:
Directed evolution is a powerful means in academic study and industrial application to modified and functionally improved proteins. There have been significant and impressive advances using the artificial method. Rational Evolutionary Design utilizes structural and sequence alignment information to create new genes and proteins. Rational Evolutionary Design has recently emerged as an attractive approach for studying function of proteins. The review mainly introduced four aspects: preferred codon usage, structural and sequence alignment, key domain analysis, site-directed recombination.
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