Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Alpha MSH-induced excessive grooming behavior involves a GABAergic mechanism.

S R De Barioglio1, N Lezcano, M E Celis

  • 1Dpto. de Farmacología, Facultad de Ciencias Químicas Universidad Nacional de Córdoba, Argentina.

Peptides
|January 1, 1991
PubMed
Summary

Melanocyte-stimulating hormone (MSH) and GABAergic systems interact in the ventral tegmental area (VTA) to influence excessive grooming behavior (EGB). This study reveals a complex interplay between GABA, acetylcholine, and MSH in the VTA.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ghrelin treatment leads to dendritic spine remodeling in hippocampal neurons and increases the expression of specific BDNF-mRNA species.

Neurobiology of learning and memory·2021
Same author

Early effects of Epac depend on the fine-tuning of the sarcoplasmic reticulum Ca<sup>2+</sup> handling in cardiomyocytes.

Journal of molecular and cellular cardiology·2017
Same author

Gabaergic control of anxiety-like behavior, but not food intake, induced by ghrelin in the intermediate medial mesopallium of the neonatal chick.

Hormones and behavior·2014
Same author

Ghrelin increases memory consolidation through hippocampal mechanisms dependent on glutamate release and NR2B-subunits of the NMDA receptor.

Psychopharmacology·2014
Same author

Hippocampal effects of neuronostatin on memory, anxiety-like behavior and food intake in rats.

Neuroscience·2011
Same author

Different chronic cocaine administration protocols induce changes on dentate gyrus plasticity and hippocampal dependent behavior.

Synapse (New York, N.Y.)·2010

Area of Science:

  • Neuroscience
  • Behavioral Neuroscience

Background:

  • Melanocyte-stimulating hormone (MSH) administration in the ventral tegmental area (VTA) is known to induce excessive grooming behavior (EGB) via an acetylcholinergic pathway.
  • The role of the GABAergic system in MSH-induced EGB remains to be fully elucidated.

Purpose of the Study:

  • To investigate the potential involvement of the GABAergic system in excessive grooming behavior (EGB) induced by melanocyte-stimulating hormone (MSH) in the ventral tegmental area (VTA).

Main Methods:

  • Administered GABA antagonist bicuculline into the VTA to assess its effect on EGB.
  • Pretreated animals with atropine to observe its interaction with bicuculline's effect.
  • Administered bicuculline before MSH to evaluate combined effects on EGB.

Related Experiment Videos

Main Results:

  • VTA injection of bicuculline alone significantly stimulated EGB.
  • Pretreatment with atropine abolished the EGB-stimulating effect of bicuculline.
  • Co-administration of bicuculline and MSH resulted in a marked increase in EGB compared to MSH alone.

Conclusions:

  • GABA, acetylcholine (ACh), and MSH interact within the VTA to regulate EGB.
  • Elevated MSH levels appear to stimulate cholinergic neurons.
  • GABAergic fibers likely modulate cholinergic discharge presynaptically, influencing EGB.