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Thrombosis in children with malignancy.

Laszlo Bajzar1, Anthony K Chan, Mary Patricia Massicotte

  • 1Pediatric Thrombosis Program, Alberta, Canada.

Current Opinion in Pediatrics
|February 14, 2006
PubMed
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Pediatric thrombosis is increasingly recognized as a complication of childhood cancer. This review highlights the association, diagnostic challenges, and treatment considerations for thrombosis in pediatric oncology patients.

Area of Science:

  • Pediatric Oncology
  • Hematology
  • Vascular Biology

Background:

  • The link between thrombosis and malignancy is established in adults.
  • Advances in pediatric cancer treatment have led to increased survival rates, revealing new complications like thrombosis.
  • Thrombosis in children with cancer presents significant morbidity and mortality risks.

Purpose of the Study:

  • To review the association between thrombosis and malignancy in pediatric patients.
  • To discuss the epidemiology, diagnosis, and evidence-based treatment of thrombosis in this cohort.
  • To highlight the challenges in managing thrombosis in children with cancer.

Main Methods:

  • Literature review of existing studies on pediatric thrombosis and malignancy.
  • Analysis of epidemiological data related to thrombosis in childhood cancers.

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  • Synthesis of current diagnostic techniques and treatment strategies.

    • Main Results:

    • Thrombin plays a role in the interplay between malignancy, metastases, and inflammation.
    • Diagnostic accuracy for upper venous system thrombosis depends on the imaging modality used.
    • Antithrombotic therapy in pediatric oncology is complicated by bleeding risks, such as thrombocytopenia and typhlitis.

    Conclusions:

    • A clear association exists between thrombosis and malignancy in children.
    • Further research is needed to define the epidemiology of thrombosis across various pediatric malignancies.
    • Optimized diagnostic and therapeutic strategies for pediatric thrombosis are urgently required.