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Updated: Aug 11, 2026

Cercarial Transformation and in vitro Cultivation of Schistosoma mansoni Schistosomules
Published on: August 16, 2011
Heterogeneity of class I and class II MHC sequences in Schistosoma mansoni
Ayumi Okada1, Atsuko Imase, Hajime Matsuda
1Center for Arts and Humanities, Ibaraki Prefectural University of Health Sciences, Ami 4669-2, Ami, Inashiki, Ibaraki, 300-0394, Japan.
Abstract:
We investigated the genetic variations in class I and class II major histocompatibility complex (MHC) genes of Schistosoma mansoni and the effects of host MHC genotypes. S. mansoni was maintained in combinations of two mouse strains with different MHC genotypes, and the MHC gene sequences of the cercariae were investigated. The detected class I MHC gene sequences were variable, with high similarity between the H-2D(b) murine host and the parasite. For other combinations, however, the parasite sequence was homologous to those of anthropoids. All class II MHC sequences detected in S. mansoni were homologous to those of anthropoids. Our results suggest that the genetic variation in the MHC sequences of S. mansoni is derived in part from the current host, indicating horizontal transfer of the sequences from mammal to parasite.
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