Related Experiment Video
Updated: Aug 11, 2026

A Methodological Protocol and Considerations for Transcranial Ultrasonic Stimulation in Exploratory Clinical Human Studies
Published on: December 12, 2025
Application of transcranial sonography in extrapyramidal disorders: updated recommendations
1Hertie Institute for Clinical Brain Research and Institute for Medical Genetics, University of Tübingen, Hoppe-Seyler-Strasse 3, D-72076 Tübingen, Germany. daniela.berg@uni-tuebingen.de
Abstract:
Transcranial sonography (TCS) has been proven to be a valuable tool in the diagnosis and differential diagnosis of extrapyramidal disorders, supplementing clinical and pathophysiological information that may be obtained by other neuroimaging techniques. Growing interest and increased application of TCS in extrapyramidal disorders require adherence to standardised principles concerning examination procedure and parameter settings of the ultrasound machine in order to ensure comparable results. This article provides an overview of these principles and typical findings in distinct extrapyramidal disorders.

