Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Proteomics

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Integrated proteogenomic and metabolomic profiling of acute myeloid leukemias to identify molecular subtypes and associated therapy targets.

Nature cancer·2026

Same author

A Canadian Survey of Prescribing Practices of Erythropoiesis-Stimulating Agents in Dialysis-Dependent and Non-Dialysis-Dependent Chronic Kidney Disease.

Canadian journal of kidney health and disease·2026

Same author

Metaproteomics uncovers the functional capacity of a soil microbiome.

Scientific reports·2026

Same author

Long-term survival outcomes in young-onset colorectal cancer: A population-based cohort study.

Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland·2026

Same author

Optimized Low-Field Differential Ion Mobility Separations with High-Resolution Mass Spectrometry for Top-Down Proteomics.

Analytical chemistry·2026

Same author

Extremes of Age Versus Middle Decades of Life: A Population-Based Analysis of Colorectal Cancer Survival in Queensland, Australia.

ANZ journal of surgery·2025

Same journal

Light-Induced Proteomic Changes in Pseudomonas aeruginosa Biofilms.

Proteomics·2026

Same journal

Decade-Resolved Proteomic Profiling of Gastric Cancer FFPE Archives: Evaluating Storage-Associated Shifts and Signal Stability Over 50 Years.

Proteomics·2026

Same journal

Proteome-Scale Mining of Metal-Associated Proteins of Monkeypox Virus.

Proteomics·2026

Same journal

Optimized Sample Handling Minimizes Peptide Adsorption to Plastics to Enable High Sensitivity Evosep Based Chemical Proteomics.

Proteomics·2026

Same journal

Toward Predicting Pandemic Potential: A Comparative Analysis of Virus-Host Interactions Between Diverse Influenza A Viruses and the Human Innate Immune System.

Proteomics·2026

Same journal

Functional Divergence of Mucus in Pacific Oyster (Crassostrea gigas): Insights From Integrated Proteomic and Rheological Study.

Proteomics·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Mar 28, 2026

Mapping Dysfunctional Protein-Protein Interactions in Disease

Mapping Dysfunctional Protein-Protein Interactions in Disease

Published on: October 24, 2025

PRISM: a data management system for high-throughput proteomics.

Gary R Kiebel¹, Ken J Auberry, Navdeep Jaitly

¹Pacific Northwest National Laboratory, Richland, WA 99352, USA.

|February 14, 2006

Summary

This summary is machine-generated.

The Proteomics Research Information Storage and Management system (PRISM) offers a scalable computational platform for analyzing large proteomics datasets. It supports systems biology and biomarker discovery by integrating diverse data and analysis tools.

More Related Videos

Navigating the Mass Spectrometry-Based Proteomic Data Using Free Computational Tools

Navigating the Mass Spectrometry-Based Proteomic Data Using Free Computational Tools

Published on: August 19, 2025

Resolving Affinity Purified Protein Complexes by Blue Native PAGE and Protein Correlation Profiling

Resolving Affinity Purified Protein Complexes by Blue Native PAGE and Protein Correlation Profiling

Published on: April 1, 2017

Related Experiment Videos

Last Updated: Mar 28, 2026

Mapping Dysfunctional Protein-Protein Interactions in Disease

Mapping Dysfunctional Protein-Protein Interactions in Disease

Published on: October 24, 2025

Navigating the Mass Spectrometry-Based Proteomic Data Using Free Computational Tools

Navigating the Mass Spectrometry-Based Proteomic Data Using Free Computational Tools

Published on: August 19, 2025

Resolving Affinity Purified Protein Complexes by Blue Native PAGE and Protein Correlation Profiling

Resolving Affinity Purified Protein Complexes by Blue Native PAGE and Protein Correlation Profiling

Published on: April 1, 2017

Area of Science:

Proteomics
Systems Biology
Biomarker Discovery
Bioinformatics

Background:

Large-scale proteomics research requires advanced informatics tools for analyzing diverse, high-volume data.
Effective data processing and management are crucial for computational platforms in proteomics.
Platforms must offer high-throughput capabilities and flexibility for evolving analysis methods.

Purpose of the Study:

To introduce the Proteomics Research Information Storage and Management system (PRISM) as a computational platform.
To detail PRISM's suitability for the accurate mass and time tag approach in proteomics.
To highlight PRISM's scalability and adaptability for advanced proteomics research.

Main Methods:

Development of the Proteomics Research Information Storage and Management system (PRISM).
Implementation of a state machine for integrating diverse analysis tools and distributed computational nodes.
Utilizing PRISM for data processing, management, and high-throughput analysis in proteomics.

Main Results:

PRISM provides a robust platform for proteomics data analysis, supporting the accurate mass and time tag approach.
The system demonstrates significant scalability, effectively managing increasing data volumes over several years.
PRISM's architecture allows for the incorporation of new and improved data analysis tools.

Conclusions:

PRISM is an effective computational platform for advanced proteomics research, including systems biology and biomarker discovery.
The system's design ensures adaptability and scalability, crucial for the evolving field of proteomics.
PRISM facilitates high-throughput data analysis, enhancing the efficiency and accuracy of proteomics studies.