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Drug eruptions at five institutes in Bangkok
Siripen Puavilai1, Nopadon Noppakun, Chasuree Sitakalin
1Division of Dermatology, Department of Medicine, Ramathibodi Hospital Medical School, Mahidol University, Bangkok 10400, Thailand.
Journal of the Medical Association of Thailand = Chotmaihet Thangphaet
|February 14, 2006
Summary
Antimicrobial agents, particularly cephalosporins, were the leading cause of drug eruptions in Bangkok. Maculopapular rash was the most frequent clinical manifestation observed in patients.
Area of Science:
- Dermatology
- Pharmacology
- Clinical Medicine
Background:
- Drug eruptions are a common adverse drug reaction.
- Identifying causative agents and clinical patterns is crucial for patient management.
Purpose of the Study:
- To investigate the epidemiological characteristics of drug eruptions.
- To identify the most common causative drugs and clinical presentations in a Thai population.
Main Methods:
- Prospective study conducted in five Bangkok hospitals over one year (2001).
- Inclusion of 212 in- and outpatients with drug eruptions.
- Diagnosis confirmed via physical examination, history, skin biopsy, and oral challenge tests in select cases.
Main Results:
- Antimicrobial agents were the most frequent cause, with cephalosporins being the highest-ranking subgroup.
- Maculopapular rash was the predominant clinical manifestation, followed by urticaria and photosensitivity.
- Newer antimicrobial, anti-inflammatory, and lipid-lowering agents were also identified as potential causes.
Conclusions:
- Antimicrobial agents are the primary culprits in drug eruptions.
- Maculopapular eruption is the most common clinical presentation.
- A diverse range of medications can trigger various drug eruption patterns.
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