[Study on the intercellular molecule-1 polymorphisms in an Chinese population with myocardial infarction]

Area of Science:

• Genetics
• Cardiovascular Disease Research
• Molecular Biology

Background:

• Intercellular adhesion molecule-1 (ICAM-1) plays a role in inflammatory processes relevant to cardiovascular health.
• Genetic variations in ICAM-1 may influence susceptibility to myocardial infarction (MI).

Purpose of the Study:

• To investigate the association between ICAM-1 gene polymorphisms (+ 12959G/A and + 13848A/G) and the risk of myocardial infarction (MI).

Main Methods:

• Genotyping of ICAM-1 polymorphisms using Polymerase Chain Reaction-Sequence Specific Primers (PCR-SSP) and PCR-Restriction Fragment Length Polymorphism (PCR-RFLP).
• Analysis of 165 MI patients and 199 healthy controls.
• Measurement of plasma lipid and high-sensitivity C-reactive protein levels.

Main Results:

• The ICAM-1 + 12959G/A polymorphism was not detected in the study population.
• A statistically significant difference in genotype frequencies for the ICAM-1 + 13848A/G polymorphism was observed between MI patients and controls (P<0.05).
• The AA genotype of the + 13848A/G polymorphism was associated with a 1.651-fold increased risk of MI (OR = 1.651, 95% CI: 1.089-2.504).

Conclusions:

• The ICAM-1 + 12959G/A polymorphism is not present in the Chinese population studied.
• The ICAM-1 + 13848A/G polymorphism in exon 6 is associated with myocardial infarction in Chinese individuals.
• Allele A of the ICAM-1 + 13848A/G polymorphism may act as a risk factor for MI in this population.