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Is there an intestinal natriuretic factor?

O Lundgren¹, G C Hansson

¹Department of Physiology, University of Gothenburg, Sweden.

Acta Physiologica Scandinavica

|January 1, 1991

Summary

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Researchers identified a natriuretic factor in cat intestinal tissue. This factor, found in pooled fraction 3, increased sodium and water excretion in rats without inhibiting Na,K-ATPase.

Area of Science:

Physiology
Biochemistry

Background:

The regulation of sodium and water balance is crucial for maintaining cardiovascular homeostasis.
The identification of endogenous natriuretic factors is an active area of research.

Purpose of the Study:

To investigate the presence of a natriuretic factor in feline intestinal tissue.
To characterize the biochemical properties of this potential factor.

Main Methods:

Cat intestinal tissue was fractionated using ultrafiltration and gel chromatography.
Fractions were tested for inhibition of Na,K-ATPase (sodium-potassium ATPase).
Natriuretic activity was assessed in anesthetized rats by measuring renal excretion of sodium and water.

Main Results:

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A specific fraction (pooled fraction 3), lacking Na,K-ATPase inhibitory activity, significantly increased renal sodium and water excretion in rats.

Other fractions did not show consistent natriuretic effects.

No natriuretic activity was detected in fractionated cardiac tissue.

Conclusions:

The feline small intestine contains a factor with natriuretic properties.
This factor appears to act independently of Na,K-ATPase inhibition.