Related Experiment Videos
Histamine H2-receptor in atrium: signal transduction and response
K Ozawa1, Y Fujishima, T Segawa
1Department of Pharmacology, Hiroshima University School of Medicine, Japan.
Agents and Actions. Supplements
|January 1, 1991
Abstract:
We have examined the signal transduction for H2-receptor mediated positive chronotropic response of guinea-pig right atrium. Our results indicate that phospholipid methylation is rapidly induced by histamine acting on H2-receptor in guinea-pig right atrium and therefore plays a predominant role in the signal transfer of H2-receptor-mediated cyclic AMP generation to exert positive chronotropic effect of atrium, as well as GTP-binding protein activation.