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Induction of Ocular Surface Inflammation and Collection of Involved Tissues
Published on: August 4, 2022
Localized periorbital edema induced by Ibuprofen
Piti Palungwachira1, Pranee Palungwachira, Hideoki Ogawa
1Srinakharinwirot University Skin Center, Srinakharinwirot University, Sukhumvit, Bangkok, Thailand.
The Journal of Dermatology
|February 14, 2006
Summary
This study reports a rare case of periorbital edema caused by ibuprofen sensitivity. Pretreatment with terfenadine allowed ibuprofen tolerance, suggesting a histamine-mediated reaction.
Area of Science:
- Dermatology
- Pharmacology
- Allergy and Immunology
Background:
- Ibuprofen sensitivity can manifest in various ways.
- Periorbital edema is a rare presentation of drug sensitivity.
- Chronic urticaria is often associated with NSAID sensitivity.
Observation:
- A patient developed localized periorbital edema within one hour of ingesting 200 mg of ibuprofen.
- No systemic symptoms were noted, and other nonsteroidal anti-inflammatory drugs (NSAIDs) were tolerated.
- The patient tolerated ibuprofen without side effects after pretreatment with terfenadine.
Findings:
- This case highlights a unique ibuprofen-induced periorbital edema in a patient without chronic urticaria.
- The successful tolerance of ibuprofen after terfenadine pretreatment suggests a significant role for histamine in the reaction.
- This is the first documented instance of periorbital edema specifically linked to ibuprofen.
Implications:
- Histamine appears to be a key mediator in this specific type of ibuprofen-induced skin reaction.
- Terfenadine may be a viable prophylactic treatment for individuals with ibuprofen sensitivity presenting with periorbital edema.
- Further research into histamine-mediated NSAID reactions is warranted.
