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Two cDNAs encoding novel human FGF receptor.

M Seno1, R Sasada, T Watanabe

  • 1Biotechnology Research Laboratories, Takeda Chemical Industries, Ltd., Osaka, Japan.

Biochimica Et Biophysica Acta
|June 13, 1991
PubMed
Summary
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Researchers identified two novel human fibroblast growth factor (FGF) receptors, closely related to the bek oncogene. These receptors exhibit distinct membrane-bound and secreted forms, influencing cellular signaling pathways.

Area of Science:

  • Molecular Biology
  • Genetics
  • Cell Biology

Background:

  • Fibroblast Growth Factors (FGFs) are crucial signaling molecules involved in various biological processes.
  • FGF receptors (FGFRs) mediate FGF signaling, playing roles in development, cell growth, and disease.
  • The oncogene bek is known to be involved in certain cancers.

Purpose of the Study:

  • To isolate and characterize novel human fibroblast growth factor (FGF) receptors.
  • To investigate the relationship of these novel receptors to the known oncogene bek.
  • To determine the cellular localization and expression patterns of the novel FGF receptor products.

Main Methods:

  • Isolation of complementary DNAs (cDNAs) encoding novel human FGF receptors.
  • Transient expression of these cDNAs in COS cells.

Related Experiment Videos

  • Analysis of the expression products to determine their cellular localization (membrane-bound vs. secreted).

    • Main Results:

    • Two distinct types of cDNAs encoding novel human FGF receptors were successfully isolated.
    • These novel FGF receptors show close homology to the oncogene bek.
    • Expressed products were found to be membrane-bound, while products from extracellular domain regions were secreted into the culture medium.

    Conclusions:

    • Discovery of novel human FGF receptors with implications for FGF signaling pathways.
    • The findings suggest potential roles for these receptors in both normal cellular functions and oncogenesis.
    • Understanding the differential expression (membrane-bound vs. secreted) is key to deciphering their biological functions.