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ADAMTS proteinases: potential therapeutic targets?
1Rheumatology Research Unit, Level E6 (Box 194), Addenbrooke's Hospital, Hills Road, Cambridge, CB2 2QQ, UK. gjj23@cam.ac.uk
Current Pharmaceutical Biotechnology
|February 14, 2006
Summary
ADAMTS proteinases are linked to connective tissue disorders. Targeting their synthesis and processing offers potential therapeutic strategies for conditions like arthritis and Ehlers-Danlos syndrome.
Area of Science:
- Biochemistry
- Molecular Biology
- Pathology
Background:
- ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) proteinases are implicated in connective tissue pathologies.
- Conditions linked to ADAMTS proteinases include Ehlers-Danlos syndrome type VII C, Weill-Marchesani syndrome, encephalomyelitis, and arthritis.
Purpose of the Study:
- To explore ADAMTS proteinases as therapeutic targets.
- To identify potential intervention points in ADAMTS proteinase synthesis and activity.
Main Methods:
- Review of recent research on ADAMTS proteinase regulation.
- Analysis of therapeutic intervention points at transcriptional, post-transcriptional, translational, and post-translational levels.
Main Results:
- ADAMTS proteinase activity is regulated at multiple levels, including transcription, RNA splicing, translation, and proteolytic processing.
- Direct inhibition and targeting of synthesis/processing are potential therapeutic strategies.
Conclusions:
- ADAMTS proteinases are significant targets for treating connective tissue disorders.
- Interventions at various regulatory levels, including transcription and protein processing, show therapeutic promise.