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Updated: Aug 11, 2026

Biosensor-based High Throughput Biopanning and Bioinformatics Analysis Strategy for the Global Validation of Drug-protein Interactions
Published on: December 1, 2020
Macromolecular and nanotechnological modification of camptothecin and its analogs to improve the efficacy
Hiraku Onishi1, Yoshiharu Machida
1Department of Drug Delivery Research, Hoshi University, 2-4-41, Ebara, Tokyo 142-8501, Japan. onsihi@hoshi.ac.jp
Abstract:
Camptothecin (CPT) and its analogs are some of the most potent antitumor agents known. However, their poor water-solubility and high toxicity require changes of their physicochemical and biological characteristics. Active lactone forms have provoked interest in the utility of CPT and its analogs again. Macromolecular chemical modifications and nanotechnological formulations have been used to obtain improved systems of CPT-related compounds. In these systems, one of the most important concepts is the enhanced permeability and retention (EPR) effect. The outcomes obtained by these approaches are displayed by introducing concrete examples.
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