Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Microdialysis in drug discovery.

Christian Höcht1, Javier A W Opezzo, Carlos A Taira

  • 1Department of Pharmacology, Faculty of Pharmacy and Biochemistry, University of Buenos Aires, Junín 956, (C1113AAD) Buenos Aires, Argentina. chocht@ffyb.uba.ar

Current Drug Discovery Technologies
|February 14, 2006
PubMed
Summary

Microdialysis offers continuous drug monitoring and analysis, aiding pharmacokinetic and pharmacodynamic studies. This technique enables detailed investigation of drug distribution, metabolism, and effects in various tissues and physiological systems.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Micellar Co-Delivery of Fulvestrant and Quercetin to enhance oral Bioavailability: A potential Bioenhancement strategy.

International journal of pharmaceutics·2025
Same author

Biopharmaceutical evaluation of benznidazole-loaded microparticles: In vitro and in vivo studies.

International journal of pharmaceutics·2025
Same author

Alteration in hippocampal mitochondria ultrastructure and cholesterol accumulation linked to mitochondrial dysfunction in the valproic acid rat model of autism spectrum disorders.

Psychopharmacology·2025
Same author

Development of benznidazole orally disintegrating tablets for paediatric patients.

The Journal of pharmacy and pharmacology·2025
Same author

Efavirenz Repurposing Challenges: A Novel Nanomicelle-Based Antiviral Therapy Against Mosquito-Borne Flaviviruses.

Pharmaceutics·2025
Same author

[Therapeutic monitoring of itraconazole in patients with chronic pulmonary aspergillosis: a possible solution to a frequent problem].

Medicina·2024

Area of Science:

  • Pharmacology
  • Neuroscience
  • Biomedical Engineering

Background:

  • Microdialysis has evolved over 25 years, initially for studying brain function and endogenous compounds.
  • Its application expanded in the late eighties to drug measurement, offering continuous plasma sampling.
  • The technique is crucial for understanding drug behavior in biological systems.

Purpose of the Study:

  • To review the extensive applications of microdialysis in drug pharmacokinetic and pharmacodynamic research.
  • To highlight its utility in studying drug metabolism, distribution, and protein binding.
  • To emphasize its role in pharmacokinetic-pharmacodynamic (PK-PD) modeling and reverse microdialysis applications.

Main Methods:

  • Continuous plasma sampling without repeated venipuncture.

Related Experiment Videos

  • In vivo microdialysis probe implantation in various tissues (CNS, adipose, heart).
  • Simultaneous measurement of physiological parameters (blood pressure, activity).
  • Reverse microdialysis for localized drug action studies.

    • Main Results:

    • Enables continuous monitoring of drug levels and endogenous substances.
    • Facilitates detailed studies of drug distribution and metabolism.
    • Allows investigation of drug effects on neurotransmission and metabolism.
    • Supports integrated pharmacokinetic-pharmacodynamic (PK-PD) analysis and modeling.
    • Reverse microdialysis reveals local drug actions in specific tissues.

    Conclusions:

    • Microdialysis is a versatile tool for comprehensive drug pharmacokinetic and pharmacodynamic evaluation.
    • It provides valuable insights into drug behavior, efficacy, and safety across different biological contexts.
    • The technique is indispensable for advancing drug development and therapeutic strategies.