Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cardiac resynchronisation therapy for heart failure.

J A Mariani1, P A Gould, A Broughton

  • 1Department of Cardiology, The Alfred Hospital, Melbourne, Australia. justin.mariani@baker.edu.au

Internal Medicine Journal
|February 14, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Heart Failure with Preserved Ejection Fraction Conundrum-Redefining the Problem and Finding Common Ground?

Current heart failure reports·2020
Same author

Paclitaxel drug-coated balloon angioplasty for the treatment of failing arteriovenous fistulas: a single-center experience.

Acta chirurgica Belgica·2019
Same author

Targets for Heart Failure With Preserved Ejection Fraction.

Clinical pharmacology and therapeutics·2017
Same author

Norepinephrine transporter expression is inversely associated with glycaemic indices: a pilot study in metabolically diverse persons with overweight and obesity.

Obesity science & practice·2016
Same author

Methamphetamine-associated cardiomyopathy: patterns and predictors of recovery.

Internal medicine journal·2016
Same author

Cardiac resynchronisation therapy in 2015: keeping up with the pace.

Internal medicine journal·2015
Same journal

Crossover effect: causal machine learning reveals opposing mortality responses to mean arterial pressure targets among phenotypically distinct hypertensive patients with septic shock.

Internal medicine journal·2026
Same journal

Clinicopathological findings, correlations and outcomes in patients with renal disease and living with antiretroviral-treated human immunodeficiency virus infection.

Internal medicine journal·2026
Same journal

Approach to thyroid disorders associated with immune checkpoint inhibitors and tyrosine kinase inhibitors.

Internal medicine journal·2026
Same journal

A scoping review of specialist hypertension clinics.

Internal medicine journal·2026
Same journal

Thirty-day mortality among patients admitted due to acute myocardial infarction during the dates of the Cardiac Society of Australia and New Zealand Annual Scientific Meeting.

Internal medicine journal·2026
Same journal

Denosumab discontinuation and fracture risk: getting the balance right.

Internal medicine journal·2026
See all related articles

Cardiac resynchronisation therapy (CRT) improves heart failure outcomes in select patients with left bundle branch block (LBBB). Identifying non-responders is crucial for optimizing CRT effectiveness in heart failure management.

Area of Science:

  • Cardiology
  • Biomedical Engineering

Background:

  • Heart failure (HF) is a progressive condition characterized by structural and electrical remodeling.
  • Left bundle branch block (LBBB) is common in HF patients, leading to mechanical dyssynchrony.
  • Cardiac resynchronisation therapy (CRT) aims to resynchronize the failing heart.

Purpose of the Study:

  • To review the established benefits of CRT in heart failure patients.
  • To address the issue of CRT non-responders.
  • To highlight ongoing research into identifying CRT responders.

Main Methods:

  • Review of large, randomized clinical trials on CRT.
  • Analysis of patient populations and response rates to CRT.
  • Discussion of current research directions for patient selection.

Related Experiment Videos

Main Results:

  • CRT has demonstrated functional and mortality benefits in selected HF patients.
  • A significant proportion of patients do not respond to CRT.
  • Research is ongoing to identify predictors of CRT response.

Conclusions:

  • CRT is an effective therapy for a subset of heart failure patients with LBBB.
  • Patient selection remains a critical factor for successful CRT.
  • Further research is needed to improve patient selection and outcomes.