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[In vitro immunization of human lymphocytes with Epstein-Barr virus capsid antigen]
Biulleten' Eksperimental'Noi Biologii I Meditsiny
|January 1, 1991
Abstract:
Conditions for in vitro immunization of human lymphocytes from adult peripheral blood, tonsils and cord blood with Epstein-Barr Virus (EBV) capsid antigens have been studied. Pokeweed mitogen and B cell growth factor from Namalva cell line were shown to induce a significant production of specific antibodies by human lymphocytes stimulated with EBV. This effect made it possible to generate primary immune response in vitro using lymphocytes from EBV seronegative donors.