[The effect of anoxia on changes in the phosphoinositide content and bioelectrical activity in the cat cerebral...

The dynamic of the phosphatidylinositol (PI), the phosphatidylinositol 4-phosphate (PIP) and the phosphatidylinositol-4,5-diphosphate (PIP2) contents were studied in the correlation with the neuronal spike activity in cat brain cortex under acute oxygen deficiency caused by cessation of artificial ventilation for 1, 2.5 and 5 min. It was shown that the 1-min anoxia produced the depression of both PIP and PIP2 contents. The depression was followed by the development of the 'asphyxia neuronal activation'. During 2.5 and 5 min of anoxia the decrease of PIP2 content and increase of PIP one were detected against a background of neuronal bioelectrical activity depression. The PI content was constant during all the anoxic period.