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Related Experiment Videos

[Extrapancreatic tumour-induced hypoglycaemia].

Rasmus Rabøl1, Jens Frystyk Nielsen, Preben Kirkegaard

  • 1Storstrøms Sygehus, Medicinsk afdeling, Arhus Universitetshospital, Medicinsk Forskningslaboratorium, Klinisk Institut og H:S Rigshospitalet, Patologiafdeling PA, og Kirurgisk Gastroenterologisk Klinik CTX .

Ugeskrift for Laeger
|February 14, 2006
PubMed
Summary

A liver tumor caused hypoglycemia by producing excessive insulin-like growth factor II (IGF-II). Surgical removal of the benign tumor normalized blood glucose and IGF-II levels, resolving symptoms.

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Area of Science:

  • Endocrinology
  • Oncology
  • Hepatology

Background:

  • Hypoglycemia can present with diverse symptoms, including neuroglycopenic effects.
  • Acromegaloid facial features can be associated with endocrine disorders.
  • Insulin-like growth factor II (IGF-II) plays a role in glucose regulation.

Observation:

  • A 53-year-old non-diabetic male presented with hypoglycemia, neuroglycopenic symptoms, and acromegaloid facial swelling.
  • Suppressed serum insulin levels contrasted with markedly elevated free insulin-like growth factor II (IGF-II) concentrations.
  • A large, benign, solid, fibrous liver tumor was identified via CT scan.

Findings:

  • Histological examination confirmed a benign solid fibrous tumor of the liver.
  • A hemihepatectomy successfully removed the 3.6 kg liver tumor.

Related Experiment Videos

  • Post-surgery, the patient's blood glucose normalized, free IGF-II levels returned to normal, and acromegaloid facial features resolved.

    • Implications:

    • This case highlights a rare cause of hypoglycemia due to a benign liver tumor producing IGF-II.
    • Surgical resection is an effective treatment for IGF-II-mediated hypoglycemia.
    • Normalizing IGF-II levels can reverse associated clinical manifestations such as acromegaloid features.