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Endocervical glandular involvement is associated with high-grade SIL
Chandandeep S Nagi1, Peter W Schlosshauer
1Department of Pathology, The Mount Sinai School of Medicine, One Gustave L. Levy Place, Box 1194, New York, NY 10029, USA.
Gynecologic Oncology
|February 14, 2006
Summary
Endocervical glandular involvement (EGI) is four times more common in high-grade squamous intraepithelial lesions (SIL) than low-grade SIL. This finding aids in diagnosing high-grade SIL when grading is challenging.
Area of Science:
- Gynecologic pathology
- Cervical cancer screening
Background:
- Squamous intraepithelial lesions (SIL) are precancerous changes in the cervix.
- Endocervical glandular involvement (EGI) is the presence of SIL within the cervical glands.
Purpose of the Study:
- To determine the association between EGI and SIL grade.
- To evaluate the diagnostic utility of EGI in grading SIL.
Main Methods:
- Retrospective review of 200 cervical SIL cases.
- Histologic examination of cervical tissue sections.
Main Results:
- EGI was found in 9.7% of low-grade SIL and 38.3% of high-grade SIL (P = 0.001).
- The relative risk of EGI in high-grade SIL versus low-grade SIL was 3.95.
Conclusions:
- EGI is significantly more frequent in high-grade SIL.
- The presence of EGI supports a diagnosis of high-grade SIL, particularly in equivocal cases.