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Updated: Aug 11, 2026

The Application of 1% Methylene Blue Dye As a Single Technique in Breast Cancer Sentinel Node Biopsy
Published on: June 1, 2019
Patients blue on patent blue: an adverse reaction during four sentinel node procedures
E Beenen1, D B W de Roy van Zuidewijn
1Medisch Centrum Leeuwarden, Henri Dunantweg 2, 8934 AD Leeuwarden, The Netherlands.
Abstract:
Patent blue V is a well-known dye for visualisation of the lymph nodes in a sentinel lymph node biopsy in breast carcinoma. We present four cases of an adverse reaction to patent blue V, one of which was an anaphylactic shock. The adverse reactions to patent blue and isosulphan blue as found in the literature are discussed and an alternative is suggested.
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