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Cryptogenic invasive Klebsiella pneumoniae liver abscess syndrome

Fadi Braiteh1, Marjorie P Golden

  • 1Phase I Program, Division of Cancer Medicine, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Blvd, Unit 422, Houston, TX 77030-4009, USA. fbraiteh@mdanderson.org

International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases
|February 14, 2006
PubMed
Abstract

Insights

Klebsiella pneumoniae liver abscesses present distinct syndromes. A rare invasive form, CIKPLA, typically seen in Asia, is now identified in North America, requiring physician awareness.

Area of Science:

  • Infectious Diseases
  • Hepatology
  • Microbiology

Background:

  • Klebsiella pneumoniae is a significant cause of liver abscesses with unique clinical and epidemiological characteristics.
  • Liver abscesses require prompt diagnosis and management due to potential complications.

Observation:

  • A case of Klebsiella pneumoniae-associated liver abscess with septic organ spread in an American patient is presented.
  • Three distinct Klebsiella pneumoniae liver abscess syndromes were identified: polymicrobial, monomicrobial noninvasive, and monomicrobial invasive (CIKPLA).

Findings:

  • The monomicrobial cryptogenic invasive K. pneumoniae-associated liver abscess (CIKPLA) syndrome primarily affects diabetic patients in Southeast Asia.
  • CIKPLA syndrome is characterized by invasive disease and septic spread to other organs.
  • Community-acquired liver abscesses in the USA are typically noninvasive and affect Asian or Hispanic individuals.

Implications:

  • CIKPLA syndrome, previously considered rare in North America, can occur in this region.
  • Physicians in North America must be vigilant for CIKPLA syndrome, even in non-traditional patient demographics.
  • Awareness of CIKPLA syndrome is crucial for timely diagnosis and effective treatment of invasive Klebsiella pneumoniae liver disease.

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