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Photorefractive keratectomy with intraoperative mitomycin-C application
Dong H Lee1, Hak Sung Chung, Young C Jeon
1Department of Ophthalmology, Yonsei Eye Center, Seoul, South Korea. donghlee64@hananet.net
Journal of Cataract and Refractive Surgery
|February 14, 2006
Summary
Photorefractive keratectomy (PRK) with mitomycin-C (MMC) safely improved vision for over 1000 eyes. This effective refractive surgery achieved excellent visual acuity with minimal complications like haze or regression.
Area of Science:
- Ophthalmology
- Refractive Surgery
- Corneal Surgery
Background:
- Refractive errors like myopia require surgical correction.
- Photorefractive keratectomy (PRK) is a common laser eye surgery.
- Mitomycin-C (MMC) is used to inhibit fibroblast proliferation and reduce haze post-PRK.
Purpose of the Study:
- To evaluate the efficacy and safety of PRK with intraoperative mitomycin-C (MMC).
- To assess visual outcomes and complication rates in patients undergoing PRK with MMC.
Main Methods:
- Retrospective case series of 536 patients (1011 eyes) undergoing PRK with intraoperative MMC.
- Nidek EC-5000 excimer laser used for the procedure.
- Evaluated visual acuity, refractive error (SE), corneal haze, and endothelial cell density.
Main Results:
- Mean preoperative SE was -7.82 D; 72% of eyes were over -6.00 D.
- Postoperative SE averaged -0.14 D, with 86% within +/-0.50 D of target.
- 86% achieved 20/20 or better visual acuity; 98% achieved 20/40 or better.
- Regression (>1.00 D) occurred in 7.6% of eyes, more in severe myopia.
- Haze occurred in 3.17% of eyes, mostly mild (grade 1).
- No significant change in endothelial cell density; two cases of delayed epithelial healing.
Conclusions:
- PRK with intraoperative MMC is a safe and effective procedure.
- Excellent visual outcomes and high patient satisfaction were achieved.
- Complications were minimal, with low rates of significant haze or regression.