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Updated: Aug 11, 2026

A New Method for Inducing a Depression-Like Behavior in Rats
Published on: February 22, 2018
Depression research and treatment: are we skating to where the puck is going to be?
Patrick Luyten1, Sidney J Blatt, Boudewijn Van Houdenhove
1Department of Psychology, University of Leuven, Tiensestraat 102, 3000 Leuven, Belgium. Patrick.Luyten@psy.kuleuven.be
Abstract:
This paper critically reviews empirical findings regarding current key assumptions underlying the nature and treatment of depression which heavily rely on the DSM approach. This review shows that empirical evidence provides little support for these assumptions. In response to these findings, an etiologically based, biopsychosocial, dynamic interactionism model of depression is proposed. This model could foster further integration in research on depression and assist in the development of guidelines for the treatment of depression that are better informed by research findings and more congruent with complex clinical realities.
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