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Local Cre-mediated gene recombination in vascular smooth muscle cells in mice

Susanne M Zadelaar1, Lianne S M Boesten, Nuno M M Pires

  • 1Department of Cardiology, p/o TNO-Quality of Life Gaubius Laboratory, Leiden University Medical Centre, Zernikedreef 9, P.O. Box 2215, 2301 CE, Leiden, The Netherlands. asm.zadelaar@pg.tno.nl

Transgenic Research
|February 14, 2006
PubMed

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Conservative Site-specific Recombination and Phase Variation02:53

Conservative Site-specific Recombination and Phase Variation

Because the DNA segments are cut and reorganized in a direction-specific manner, site-specific recombination has emerged as an efficient genetic engineering technique. Flippase and Cyclization recombinases or Flp and Cre, respectively, are two members of the tyrosine recombinase family derived from bacteriophages, that are used to mediate site-specific DNA insertions, deletions, and targeted expression of proteins in mammalian cell lines.
The recognition sites for Cre recombinase called LoxP...
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To learn more about the function of a gene, researchers can observe what happens when the gene is inactivated or “knocked out,” by creating genetically engineered knockout animals. Knockout mice have been particularly useful as models for human diseases such as cancer, Parkinson’s disease, and diabetes.