Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cognitive function in multiple system atrophy of the cerebellar type.

Katrin Bürk1, Irene Daum, Udo Rüb

  • 1Department of Neurology, University of Ulm, Ulm, and Department of Neurology, University of Tübingen, Tübingen, Germany. buerk@ngi.de

Movement Disorders : Official Journal of the Movement Disorder Society
|February 14, 2006
PubMed
Summary

Multiple System Atrophy (MSA) patients with cerebellar type (MSA-C) show impaired verbal memory and fluency. These cognitive deficits in MSA-C stem from subcortical, not cerebellar, dysfunction, despite dementia being an exclusion criterion.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Predictors of Survival in Friedreich's Ataxia: A Prospective Cohort Study.

Movement disorders : official journal of the Movement Disorder Society·2023
Same author

The comorbidity and co-medication profile of patients with progressive supranuclear palsy.

Journal of neurology·2023
Same author

Cerebral venous thrombosis, neutropenia and iron-deficiency anemia in Huntington disease.

Neurodegenerative disease management·2021
Same author

Clinical spectrum of the pentanucleotide repeat expansion in the <i>RFC1</i> gene in ataxia syndromes.

Neurology·2020
Same author

Onset features and time to diagnosis in Friedreich's Ataxia.

Orphanet journal of rare diseases·2020
Same author

Aberrant functional connectivity of resting state networks related to misperceptions and intra-individual variability in Parkinson's disease.

NeuroImage. Clinical·2019

Area of Science:

  • Neuroscience
  • Neurology
  • Cognitive Science

Background:

  • Dementia is an exclusion criterion for Multiple System Atrophy (MSA).
  • Fronto-executive dysfunction has been reported in MSA of the striatonigral type (MSA-P).
  • Cognitive profiles in MSA of the cerebellar type (MSA-C) require further investigation.

Purpose of the Study:

  • To investigate the cognitive profile of patients diagnosed with MSA of the cerebellar type (MSA-C).
  • To identify specific cognitive deficits and their potential origins in MSA-C.

Main Methods:

  • A cohort of 20 patients with MSA-C underwent comprehensive neuropsychological testing.
  • Tests assessed intelligence quotient (IQ), attention, verbal and visuospatial memory, and executive functions.
  • Cognitive test performance was correlated with motor disability severity.

Related Experiment Videos

Main Results:

  • Patients with MSA-C demonstrated impairments in verbal memory and verbal fluency.
  • Cognitive performance was independent of the severity of motor symptoms.
  • Findings suggest subcortical dysfunction contributes to cognitive issues in MSA-C.

Conclusions:

  • Cognitive impairment, particularly in verbal memory and fluency, is present in MSA-C.
  • These deficits appear to originate from subcortical, rather than cerebellar, dysfunction.
  • The study highlights the importance of assessing cognitive function in MSA-C, even when dementia is not overt.