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Updated: Aug 11, 2026
Murine Model of Allergen Induced Asthma
Published on: May 14, 2012
[Role of arsenolite on 8-isoprostane of asthmatic mice plasm]
Dong-ming Li1, Jia-xing Xie, Biao Liang
1Department of Respiratory Disease, Guangdong Medical College, Zhanjiang 524001, China. lizewei@gdmc.edu.cn
Objective:
Through the establishment of mouse' ovalbumin- sensitized asthmatic model and the observation of the 8-Isoprostane of plasm, to evaluate the therapeutic effects of arsenolite on asthmatic mice.
Method:
Forty-two healthy Kunming male mice were randomly divided into control group and experience groups, the latter were treated with dexamethasone, arsenolite. Lung function were tested, 8-isoprostane of plasm and WBC of BALF were measured.
Result:
Lung function improved after treating with dexamethasone or arsenolite. The WBC of asthmatic mice were significantly higher than those in control group, and decreased after treating with dexamethasone or arsenolite; 8-Isoprostane of plasm in asthmatic mice was higher than that of control group, and decreased after treating with dexamethasone or arsenolite.
Conclusion:
There is oxidant stress status in asthmatic mice. Arsenolite could lighten airway obstruction, reduce airway high response and redress oxidant stress status in asthmatic mice.
Insights
Arsenolite treatment improved lung function and reduced airway inflammation in asthmatic mice, indicating its therapeutic potential for asthma by alleviating oxidative stress.
Area of Science:
- Immunology
- Pharmacology
- Respiratory Medicine
Background:
- Asthma is a chronic respiratory disease characterized by airway inflammation and hyperresponsiveness.
- Oxidative stress plays a significant role in the pathogenesis of asthma.
Purpose of the Study:
- To evaluate the therapeutic effects of arsenolite on a mouse model of ovalbumin-sensitized asthma.
- To investigate the impact of arsenolite on lung function, airway inflammation, and oxidative stress markers in asthmatic mice.
Main Methods:
- An ovalbumin-sensitized mouse model of asthma was established.
- Mice were treated with dexamethasone or arsenolite.
- Lung function, plasma 8-isoprostane levels, and white blood cell (WBC) counts in bronchoalveolar lavage fluid (BALF) were measured.
Main Results:
- Arsenolite treatment improved lung function in asthmatic mice.
- Arsenolite significantly reduced WBC counts in BALF and plasma 8-isoprostane levels compared to untreated asthmatic mice.
- These improvements were comparable to those observed with dexamethasone treatment.
Conclusions:
- Asthmatic mice exhibit a state of oxidative stress.
- Arsenolite effectively alleviates airway obstruction, reduces airway hyperresponsiveness, and ameliorates oxidative stress in asthmatic mice.
- Arsenolite demonstrates potential as a therapeutic agent for asthma management.
