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EGFR, c-erbB-2 and ki-67 in NSCLC and preneoplastic bronchial lesions
A P Meert1, B Martin, J M Verdebout
1Department of Intensive Care and Thoracic Oncology, Institut Jules Bordet, Brussels, Belgium. ap.meert@bordet.be
Background:
The relationships between EGF-R and c-erbB-2 with other factors involved in tumour regulation are not well understood. The aim of this study was to correlate the expression of these markers with tumour proliferation.
Materials And Methods:
The presence of EGF-R, c-erbB-2 and Ki-67 was evaluated by immunohistochemistry in non-small cell lung cancer (NSCLC) and preneoplastic lesions.
Results:
Forty-two percent of the tumours were positive for EGF-R, 22% for c-erbB-2 and 97% for Ki-67. No statistically significant correlation was found between EGF-R and Ki-67, EGF-R and c-erbB-2 or between c-erbB-2 and Ki-67. With regards to Ki-67, a significant difference in survival was noted in favour of patients who did not express the marker. In preneoplastic lesions, most of the low-grade lesions showed neither EGF-R nor Ki-67 staining. In contrast, most of the high-grade lesions stained positively for these proteins.
Conclusion:
EGF-R and c-erbB-2 do not seem to be correlated with Ki-67 in NSCLC.
