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Mannan-binding lectin in children with chronic gastritis

L Bak-Romaniszyn1, M Cedzyński, J Szemraj

  • 1Department of Paediatrics, Preventive Cardiology and Clinical Immunology, Medical University of Łódź, Łódź, Poland.

Scandinavian Journal of Immunology
|February 16, 2006
PubMed

Insights

Mannan-binding lectin (MBL) insufficiency does not appear to increase the risk of chronic gastritis in children. However, MBL

Area of Science:

  • Immunology
  • Pediatric Gastroenterology

Background:

  • Chronic gastritis (CG) in children is a significant health concern.
  • The role of mannan-binding lectin (MBL) in CG pathogenesis is not fully understood.

Purpose of the Study:

  • To investigate the involvement of MBL insufficiency in the pathogenesis of pediatric chronic gastritis.
  • To compare MBL-2 gene mutations and serum concentrations in children with and without H. pylori infection.

Main Methods:

  • Collected blood samples from 78 pediatric CG patients (H. pylori positive), 41 CG patients (H. pylori negative), and 77 controls.
  • Analyzed mbl-2 gene mutations and serum MBL protein concentrations.
  • Examined mbl-2 gene expression in gastric biopsies.

Main Results:

  • No significant differences in mbl-2 gene mutations or serum MBL concentrations were found between CG groups and controls.
  • mbl-2 gene expression was detected in gastric biopsies of CG patients.
  • Gene expression was stronger in H. pylori-infected children.

Conclusions:

  • MBL deficit/dysfunction is unlikely to be a risk factor for pediatric CG, with or without H. pylori.
  • MBL's opsonic effect and the lectin complement pathway may represent host defense mechanisms in gastric patients.

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