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Mannan-binding lectin in children with chronic gastritis
L Bak-Romaniszyn1, M Cedzyński, J Szemraj
1Department of Paediatrics, Preventive Cardiology and Clinical Immunology, Medical University of Łódź, Łódź, Poland.
Scandinavian Journal of Immunology
|February 16, 2006
Summary
Mannan-binding lectin (MBL) insufficiency does not appear to increase the risk of chronic gastritis in children. However, MBL
Area of Science:
- Immunology
- Pediatric Gastroenterology
Background:
- Chronic gastritis (CG) in children is a significant health concern.
- The role of mannan-binding lectin (MBL) in CG pathogenesis is not fully understood.
Purpose of the Study:
- To investigate the involvement of MBL insufficiency in the pathogenesis of pediatric chronic gastritis.
- To compare MBL-2 gene mutations and serum concentrations in children with and without H. pylori infection.
Main Methods:
- Collected blood samples from 78 pediatric CG patients (H. pylori positive), 41 CG patients (H. pylori negative), and 77 controls.
- Analyzed mbl-2 gene mutations and serum MBL protein concentrations.
- Examined mbl-2 gene expression in gastric biopsies.
Main Results:
- No significant differences in mbl-2 gene mutations or serum MBL concentrations were found between CG groups and controls.
- mbl-2 gene expression was detected in gastric biopsies of CG patients.
- Gene expression was stronger in H. pylori-infected children.
Conclusions:
- MBL deficit/dysfunction is unlikely to be a risk factor for pediatric CG, with or without H. pylori.
- MBL's opsonic effect and the lectin complement pathway may represent host defense mechanisms in gastric patients.
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