Related Experiment Video
Updated: Aug 11, 2026
10:01
Structure-Guided Design and Development of Novel Cyclophilin A Inhibitors and Ganoderiol-F Derivatives: An In-Silico Approach
Published on: June 23, 2026
Dealing with the family: CD147 interactions with cyclophilins
Vyacheslav Yurchenko1, Stephanie Constant, Michael Bukrinsky
1Albert Einstein College of Medicine of Yeshiva University, Bronx, NY, USA.
Immunology
|February 16, 2006
Summary
CD147 protein interactions with cyclophilins are key to immune cell signaling. Targeting these interactions shows significant anti-inflammatory effects in lung diseases and arthritis.
Area of Science:
- Molecular Biology
- Immunology
- Cell Biology
Background:
- CD147 (also known as EMMPRIN) is a plasma membrane protein involved in numerous physiological and pathological processes.
- It acts as an extracellular matrix metalloproteinase inducer and regulates immune cell functions.
- Recent findings highlight CD147's role as a signaling receptor for extracellular cyclophilins A and B.
Purpose of the Study:
- To review current knowledge on the interactions between CD147 and cyclophilins.
- To explore the role of cyclophilin-CD147 interactions in inflammatory responses.
- To summarize the therapeutic potential of targeting these interactions.
Main Methods:
- Literature review of studies investigating CD147-cyclophilin interactions.
- Analysis of research on the signaling pathways involving CD147 and cyclophilins.
- Examination of data from animal models of inflammatory diseases.
Main Results:
- Extracellular cyclophilins act as potent chemotactic agents for immune cells via CD147.
- Targeting CD147 or cyclophilins demonstrated significant anti-inflammatory effects.
- These effects were observed in animal models of acute and chronic lung diseases and rheumatoid arthritis.
Conclusions:
- The interaction between CD147 and cyclophilins plays a crucial role in immune cell chemotaxis and inflammation.
- Inhibition of CD147-cyclophilin interactions represents a promising therapeutic strategy for inflammatory conditions.
- Further research is warranted to fully elucidate the therapeutic applications of targeting this pathway.
More Related Videos
Related Concept Videos
00:50Anaphase Promoting Complex
The stepwise destruction of specific proteins is necessary for the progression and completion of the cell cycle. Such proteins are ubiquitinated by ubiquitin ligases and then subsequently destroyed by the proteasome. The SCF (Skp1/Cullin/F-box) and the anaphase-promoting complex (APC) are two important ubiquitin ligases involved in cell cycle progression. While SCF is active throughout the cell cycle, APC gets activated during metaphase to anaphase transition. Cdc20 or Cdh1 binds to APC and...
02:34Inhibition of Cdk Activity
The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
01:32Pinching-off of Coated Vesicles
Vesicle budding is orchestrated by distinct cytosolic proteins such as adaptor proteins, coat proteins, and GTPases. To initiate vesicle budding, membrane-bending proteins containing crescent-shaped BAR domains bind to the lipid heads in the bilayer and distort the membrane to form a protein-coated vesicle bud. Adaptors proteins such as AP2 for clathrin-coated vesicles can nucleate on the deformed membrane. Finally, coat proteins such as clathrin or COPI and COPII assemble into a coat forming...
02:39Positive Regulator Molecules
Mitotic cell division results in daughter cells that exactly resemble the parent cell. However, errors in the DNA replication or distribution of genetic material may lead to genetic mutations that may be passed down to every new cell formed from the resulting abnormal cell. Propagation of such mutant cells is restricted through checkpoint mechanisms present at different stages of the cell cycle. These checkpoints involve regulator molecules that either promote or demote cell cycle events.
01:19Allosteric Proteins-ATCase
Binding sites linkages can regulate a protein's function. For example, enzyme activity is often regulated through a feedback mechanism where the end product of the biochemical process serves as an inhibitor.
Aspartate transcarbamoylase (ATCase) is a cytosolic enzyme that catalyzes the condensation of L-aspartate and carbamoyl phosphate to N-carbamoyl-L-aspartate. This reaction is the first step in pyrimidine biosynthesis. UTP and CTP, the end products of the pyrimidine synthesis pathway,...
Aspartate transcarbamoylase (ATCase) is a cytosolic enzyme that catalyzes the condensation of L-aspartate and carbamoyl phosphate to N-carbamoyl-L-aspartate. This reaction is the first step in pyrimidine biosynthesis. UTP and CTP, the end products of the pyrimidine synthesis pathway,...
01:30Assembly of Signaling Complexes
Multiprotein signaling complexes are formed in a dynamic process involving protein-protein interactions at the cytoplasmic domain of transmembrane receptors or enzymatic and non-enzymatic proteins associated with the receptor. These complexes ensure the activation and propagation of intracellular signals that regulate cell functions.
Interaction domains in cell signaling
Interaction domains recognize exposed features of their binding partners containing post-translationally modified sequences,...
Interaction domains in cell signaling
Interaction domains recognize exposed features of their binding partners containing post-translationally modified sequences,...