Jove
Visualize
Contact Us

Related Experiment Videos

[Refractory anaemia successfully treated with thalidomide].

Marianne Hansen1, Per Boye Hansen

  • 1Hillerød Sygehus, Medicinsk Afdeling F, Hillerød.

Ugeskrift for Laeger
|February 16, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Psychosocial crisis management: Assisting sensory-impaired individuals in case of disasters.

Journal of emergency management (Weston, Mass.)·2025
Same author

The Wound Care Pathway: a Danish effect study.

British journal of community nursing·2024
Same author

An immunogenic first-in-human immune modulatory vaccine with PD-L1 and PD-L2 peptides is feasible and shows early signs of efficacy in follicular lymphoma.

Oncoimmunology·2024
Same author

Health Technology Readiness amongst Patients with Suspected Breast Cancer Using the READHY-tool - a Cross-sectional Study.

Journal of medical systems·2023
Same author

Ugeskrift for laeger·2023
Same author

Retraction Note to: Bismuth adjuvant ameliorates adverse effects of high-dose chemotherapy in patients with multiple myeloma and malignant lymphoma undergoing autologous stem cell transplantation: a randomised, double-blind, prospective pilot study.

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer·2020
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

This case study highlights a patient with refractory autoimmune hemolytic anemia who developed myelodysplastic syndrome. Thalidomide and prednisolone treatment effectively increased hemoglobin levels, suggesting potential for these agents in complex anemias.

Area of Science:

  • Hematology
  • Oncology

Background:

  • Autoimmune hemolytic anemia (AIHA) can present with splenomegaly and lead to transfusion-dependent anemia post-splenectomy.
  • Refractory anemia cases require exploration of novel therapeutic strategies.

Observation:

  • A 63-year-old male with AIHA and splenomegaly underwent splenectomy, resulting in severe transfusion-dependent anemia.
  • Initial treatments with prednisolone, erythropoietin, and danocrine were ineffective.
  • Subsequent bone marrow examination revealed myelodysplastic syndrome (MDS).

Findings:

  • Treatment with thalidomide (50-150 mg/d) and prednisolone (25 mg/d) led to a significant increase in hemoglobin to 8.9 mmol/l.
  • This indicates a positive response to immunomodulatory and anti-angiogenic therapy in a patient with refractory anemia and MDS.

Related Experiment Videos

Implications:

  • Immunomodulatory and anti-angiogenic agents show promise for managing complex and refractory anemia cases.
  • Further research is warranted to establish the efficacy and safety of thalidomide and similar agents in myelodysplastic syndromes.