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[Celecoxib-induced aquagenic keratoderma].

Susana Vildósola1, Aitziber Ugalde

  • 1Sección de Dermatológica, Hospital de Galdakao, Bizkaia, Spain. sve@aedv.es

Actas Dermo-Sifiliograficas
|February 16, 2006
PubMed
Summary
This summary is machine-generated.

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Aquagenic keratoderma causes water-induced skin changes on the palms. A case report suggests celecoxib may trigger these symptoms by affecting skin sodium levels.

Area of Science:

  • Dermatology
  • Pharmacology

Background:

  • Aquagenic keratoderma is a rare skin condition affecting palms after water exposure.
  • It presents as translucent papules and plaques with prominent eccrine ducts.
  • Histopathology reveals hyperkeratosis and eccrine duct dilation.

Observation:

  • A 31-year-old woman with rheumatoid arthritis developed aquagenic keratoderma.
  • Symptoms began one month after initiating celecoxib treatment.
  • Previous reports link similar changes to cystic fibrosis and rofecoxib.

Findings:

  • Celecoxib treatment is a potential trigger for aquagenic keratoderma.
  • Elevated skin sodium levels due to celecoxib may cause water retention in keratin.
  • This mechanism could explain the observed clinical symptoms.

Related Experiment Videos

Implications:

  • This case highlights a potential drug-induced etiology for aquagenic keratoderma.
  • Further research is needed to confirm the role of celecoxib and sodium levels.
  • Clinicians should consider medication history when diagnosing aquagenic keratoderma.